Do you own a V2? Try a power balance test or check your injector balance rates. New injectors should have lasted more than 10k miles, but improper installation or a leaking cup could always be a problem, not to say that manufacturer defects are unheard of.
Regarding your tune, reduce the desired boost as cruising speeds (2000-2500 RPM) on your maps. It takes fuel to make boost. Even on my hottest tune, I barely lift the needle on the boost gauge once I get on the interstate, and I get about 20 highway.
If you have some money you aren't using, get an Air Dog or a fass (fuel lift pump) and fill out your sig so we know what you're working with.
2003 Chevy 2500HD D/A ECSB 221K (Sold)
EFI Live DSP5 (thank you to Dustin and Idaho Rob @ATP Trucks), batmowheel & BD wastegate (thanks to MrManners @ Synthetic Motorsports), Kryptonite tie-rods, MBRP downpipe and 4" straight pipe, 33" BF Goodrich A/T KOs on H2s
2007 LMM/Alli CCSB 4x4 (Sold)
EFI Live and downpipe/5"
2007 Grand Prix GTP (needs headers and s#!*)