Yes reliability is an issue that is why I traded my 18 Platinum F250 for the 2020 GMC. Kept losing injectors (twice and the third time traded it because it was intermittent did not throw codes and after turning off for a few minutes it would stop for awhile Most of the time) and running like a cob in the middle of nowhere, water pump, trans case seal and the software for the "Sync" kept causing my display that controlled the radio to climate control to freeze.That's the million dollar question, I've owned all three brands. My issues have all been not major so far, never been stranded thus far and that's probably why it hasn't been traded. When reliability becomes a problem, thats when things change quickly.
Before that traded my 2016 2500 Cummins only had about 85k because of stretched head bolts let oil and coolant mix. After the repair almost 6k that FCA paid for I traded it. I just have had a run of bad luck except this current one (def reading issue fixed) so far knock on wood...