As has been said, "More Power = Less MPG" - you should read these threads over on the ford-trucks forum

Ford (and RamCummins) offer a "High Output" version of their respective oil burners. It's entertaining to watch the guys with HO engines arguing their point that the 1-2 mpg hit on mileage is "totally worth it!" for the extra power.
I've noticed my new truck does regenerate the DPF far more often than my last two L5P's (2020 and 2022) - I see the telltale grey smoke about every 200 miles now, but it seems to last about 10-15 miles at most. I would expect the more frequent regen is impacting overall MPG.
The "More Power = Less MPG" rule mostly holds true under modern emissions rules. To John's point above, yes without concern for soot and NOx these modern engines should be improving their fuel economy. The issue is that more power, coupled with tighter emissions requirements, generally equals lower overall fuel (and DEF) economy.
Here is how I console myself of the grief of loosing a few MPG (and burning more DEF) --- I tell myself, that for as long as I live in Washington state, this may be the last oil burner I get the privilege to own. Between EV mandates and Blue state CARB rules, my choices in the future will be limited to whatever those in authority allow me to buy. My wife does like the Silverado EV, which might be the only thing I can buy with a truck bed in the future... The forbidden fruit tastes all the more sweeter....